Connect Sign In
IDH1 R132H Point Mutation with Interpretation by Immunohistochemistry
Ordering Recommendation
Identify the most common IDH mutation in diffuse gliomas.
New York DOH Approval Status
Specimen Required
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin is preferred) and paraffin embed specimen. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800)522-2787. (Min. 3 slides) If sending precut slides, do not oven bake.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
This test code includes pathologist interpretation. Include surgical pathology report. When ordering, please identify tissue site. IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. If you do not have electronic ordering capability, use an ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. For additional technical details, please contact ARUP Client Services at (800) 522-2787.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Performed
Mon-Fri
Reported
1-5 days
Reference Interval
Interpretive Data
By report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
88342
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2007358 | IDH1 R132H Mutation Reference Number | 94736-6 |
| 2007359 | IDH1 R132H Point Mutation by IHC Result | 55229-9 |
| 3003120 | IDH1 Tissue Source | 31208-2 |
Aliases
- Astrocytoma and Oligodendroglioma Tumor Cell Marker
- IDH1 Point mutation IHC
- IDH1 R132H antibody staining
- IDH1 R132H IHC
